potentiometric determination of ketotifen fumarate in pharmaceutical preparations and urine using carbon paste and pvc membrane selective electrodes
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ID: 210670
2011
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Abstract
This study compares
between unmodified carbon paste (CPE; the paste
has no ion pair) and polyvinyl chloride (PVC)
membrane selective electrodes that were used in
potentiometric determination of ketotifen
fumarate (KTF), where sodium tetraphenylborate
(NaTPB) was used as titrant. The performance
characteristics of these sensors were evaluated
according to IUPAC recommendations which reveal
a fast, stable, and linear response for KTF over
the concentration range of 10−7 to
10−2 mol L−1. The
electrodes show Nernstian slope value of
52.51±0.20 and 51.51±0.25 mV decade−1 for CPE and PVC membrane
electrodes at 30∘C, respectively. The potential
is nearly stable over the pH range 3.0–6.0 and 2.0–7.0
for CPE and PVC membrane electrodes, respectively. Selectivity
coefficient values towards different inorganic cations, sugars, and
amino acids reflect high selectivity of the prepared electrodes.
The electrodes responses at different temperatures were also
studied, and long operational lifetime of 12 and 5 weeks for CPE
and PVC membrane electrodes, respectively, were found. These are
used for determination of ketotifen fumarate using potentiometric
titration, calibration, and standard addition methods in pure
samples, its pharmaceutical preparations (Zaditen tablets), and
biological fluid (urine). The direct potentiometric determination
of KTF using the proposed sensors gave recoveries % of 98.97±0.53 and 98.62±0.74 with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.
| Reference Key |
frag2011internationalpotentiometric
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|---|---|
| Authors | ;Eman Y. Z. Frag;Gehad G. Mohamed;Mohamed M. Khalil;Mohammad M. A. Hwehy |
| Journal | Pesticide biochemistry and physiology |
| Year | 2011 |
| DOI |
10.1155/2011/604741
|
| URL | |
| Keywords |
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