preventive effect of coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats
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ID: 210477
2017
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Abstract
Objective:Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure.Materials and Methods: Forty male rats were divided into five main groups and treated by (1) saline, (2) PTZ: 100 mg/kg PTZ (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract of C. sativum during seven consecutive days before PTZ injection. After electrocorticography (ECoG), the brains were removed to use for histological examination.Results: All doses of the extract reduced duration, frequency and amplitude of the burst discharges while prolonged the latency of the seizure attacks (p
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| Reference Key |
pourzaki2017avicennapreventive
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|---|---|
| Authors | ;Mojtaba Pourzaki;Mansour Homayoun;Saeed Sadeghi;Masoumeh seghatoleslam;Mahmoud Hosseini;Alireza Ebrahimzadeh Bideskan |
| Journal | Anatolian journal of cardiology |
| Year | 2017 |
| DOI |
10.22038/ajp.2016.7757
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| URL | |
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