recent advances in detecting mitochondrial dna heteroplasmic variations

Clicks: 292
ID: 209996
2018
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Abstract
The co-existence of wild-type and mutated mitochondrial DNA (mtDNA) molecules termed heteroplasmy becomes a research hot point of mitochondria. In this review, we listed several methods of mtDNA heteroplasmy research, including the enrichment of mtDNA and the way of calling heteroplasmic variations. At the present, while calling the novel ultra-low level heteroplasmy, high-throughput sequencing method is dominant while the detection limit of recorded mutations is accurate to 0.01% using the other quantitative approaches. In the future, the studies of mtDNA heteroplasmy may pay more attention to the single-cell level and focus on the linkage of mutations.
Reference Key
duan2018moleculesrecent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mengqin Duan;Jing Tu;Zuhong Lu
Journal Journal of ethnopharmacology
Year 2018
DOI
10.3390/molecules23020323
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