challenges of generating and maintaining protective vaccine-induced immune responses for foot-and-mouth disease virus in pigs

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ID: 209993
2016
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Abstract
Vaccination can play a central role in the control of outbreaks of foot-and-mouth disease (FMD) by reducing both the impact of clinical disease and the extent of virus transmission between susceptible animals. Recent incursions of exotic FMD virus lineages into several East Asian countries have highlighted the difficulties of generating and maintaining an adequate immune response in vaccinated pigs. Factors that impact upon vaccine performance include: (i) the potency, antigenic payload and formulation of a vaccine; (ii) the antigenic match between the vaccine and the heterologous circulating field strain and (iii) the regime (timing, frequency and herd-level coverage) used to administer the vaccine. This review collates data from studies that have evaluated the performance of FMDV vaccines at the individual and population level in pigs, and identifies research priorities that could provide new insights to improve vaccination in the future.
Reference Key
lyons2016frontierschallenges Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Nicholas Anthony Lyons;Nicholas Anthony Lyons;Donald Peter King;Young S Lyoo;David J Paton
Journal Current microbiology
Year 2016
DOI
10.3389/fvets.2016.00102
URL
http://journal.frontiersin.org/Journal/10.3389/fvets.2016.00102/full
Keywords
population immunity vaccination foot-and-mouth disease

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