syntheses of two deacetyl-thymosin α1 analogues and their effects on low e-rosette-forming lymphocytes of uraemic patients
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ID: 209823
1996
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Abstract
Two deacetyl-thymosin α1 analogues containing Phe (4Br) or D-Phe (4Br) residue—[D-Phe(4Br)21]deacetyl-thymosin α1 and [Phe(4Br)21]deacetyl-thymosin α1, respectively—were synthesized by the manual solid-phase method and their immunological effects on the low E-rosette-forming lymphocytes of uraemic patients were examined. One of the synthetic analogues, [Phe(4Br)21deacetyl-thymosin α1, demonstrated a restorative effect on the low E-rosette-forming lymphocytes of uraemic patients, which was stronger than that of deacetyl-thymosin α1, but the other analogue, [D-Phe(4Br)21]deacetyl-thymosin α1, showed no restorative effect under the same conditions.
| Reference Key |
abiko1996mediatorssyntheses
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|---|---|
| Authors | ;T. Abiko;H. Sekino |
| Journal | polyhedron |
| Year | 1996 |
| DOI |
10.1155/S0962935196000439
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| URL | |
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