the interactions between host glycobiology, bacterial microbiota, and viruses in the gut

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ID: 209700
2018
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Abstract
Rotavirus (RV) and norovirus (NoV) are the major etiological agents of viral acute gastroenteritis worldwide. Host genetic factors, the histo-blood group antigens (HBGA), are associated with RV and NoV susceptibility and recent findings additionally point to HBGA as a factor modulating the intestinal microbial composition. In vitro and in vivo experiments in animal models established that the microbiota enhances RV and NoV infection, uncovering a triangular interplay between RV and NoV, host glycobiology, and the intestinal microbiota that ultimately influences viral infectivity. Studies on the microbiota composition in individuals displaying different RV and NoV susceptibilities allowed the identification of potential bacterial biomarkers, although mechanistic data on the virus–host–microbiota relation are still needed. The identification of the bacterial and HBGA interactions that are exploited by RV and NoV would place the intestinal microbiota as a new target for alternative therapies aimed at preventing and treating viral gastroenteritis.
Reference Key
monedero2018virusesthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Vicente Monedero;Javier Buesa;Jesús Rodríguez-Díaz
Journal International journal of pharmaceutics
Year 2018
DOI
10.3390/v10020096
URL
http://www.mdpi.com/1999-4915/10/2/96
Keywords
norovirus microbiota rotavirus host susceptibilitymicrobiology

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