Delivery of antisense peptide nucleic acid by gold nanoparticles for the inhibition of virus replication.

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2019
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Abstract
We aim to use peptide nucleic acid (PNA) for antisense therapy against bovine viral diarrhea virus (BVDV), a surrogate model of human hepatitis C virus, and introduce an optimal approach for delivering PNA into the cell. PNA was designed for hybridization to the 5'-untranslated region of BVDV RNA in order to form a heteroduplex structure and inhibit the translation and replication of virus. Gold nanoparticles (AuNPs) were used as a delivery system for PNA. The cellular uptake of PNA-AuNPs and inhibition of BVDV infection in the middle stage of viral replication were found. Further research is warranted to develop AuNPs as a potential vehicle for delivering PNA in order to remove viruses from the infected cells.
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ghaffari2019deliverynanomedicine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ghaffari, Elnaz;Rezatofighi, Seyedeh Elham;Ardakani, Mohammad Roayaei;Rastegarzadeh, Saadat;
Journal nanomedicine (london, england)
Year 2019
DOI
10.2217/nnm-2018-0520
URL
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