Delivery of antisense peptide nucleic acid by gold nanoparticles for the inhibition of virus replication.

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ID: 2095
2019
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Ranked #4 of 23 articles by views in nanomedicine (london, england)

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Abstract
We aim to use peptide nucleic acid (PNA) for antisense therapy against bovine viral diarrhea virus (BVDV), a surrogate model of human hepatitis C virus, and introduce an optimal approach for delivering PNA into the cell. PNA was designed for hybridization to the 5'-untranslated region of BVDV RNA in order to form a heteroduplex structure and inhibit the translation and replication of virus. Gold nanoparticles (AuNPs) were used as a delivery system for PNA. The cellular uptake of PNA-AuNPs and inhibition of BVDV infection in the middle stage of viral replication were found. Further research is warranted to develop AuNPs as a potential vehicle for delivering PNA in order to remove viruses from the infected cells.
Reference Key
ghaffari2019deliverynanomedicine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ghaffari, Elnaz;Rezatofighi, Seyedeh Elham;Ardakani, Mohammad Roayaei;Rastegarzadeh, Saadat;
Journal nanomedicine (london, england)
Year 2019
DOI
10.2217/nnm-2018-0520
URL
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