ghrelin protects against dexamethasone-induced ins-1 cell apoptosis via erk and p38mapk signaling

Clicks: 248
ID: 209484
2016
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #40 of 149 articles by views in zhonghua wei zhong bing ji jiu yi xue

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 149 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Glucocorticoid excess induces apoptosis of islet cells, which may result in diabetes. In this study, we investigated the protective effect of ghrelin on dexamethasone-induced INS-1 cell apoptosis. Our data showed that ghrelin (0.1 μM) inhibited dexamethasone-induced (0.1 μM) apoptosis of INS-1 cells and facilitated cell proliferation. Moreover, ghrelin upregulated Bcl-2 expression, downregulated Bax expression, and decreased caspase-3 activity. The protective effect of ghrelin against dexamethasone-induced INS-1 cell apoptosis was mediated via growth hormone secretagogue receptor 1a. Further studies revealed that ghrelin increased ERK activation and decreased p38MAPK expression after dexamethasone treatment. Ghrelin-mediated protection of dexamethasone-induced apoptosis of INS-1 cells was attenuated using the ERK inhibitor U0126 (10 μM), and cell viability increased using the p38MAPK inhibitor SB203580 (10 μM). In conclusion, ghrelin could protect against dexamethasone-induced INS-1 cell apoptosis, at least partially via GHS-R1a and the signaling pathway of ERK and p38MAPK.
Reference Key
zhang2016internationalghrelin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chengshuo Zhang, Le Li, Bochao Zhao, Ao Jiao, Xin Li, Ning Sun, Jialin Zhang
Are you one of these authors? Claim your profile
Journal zhonghua wei zhong bing ji jiu yi xue
Year 2016
DOI
10.1155/2016/4513051
URL
http://dx.doi.org/10.1155/2016/4513051
Keywords
clinical endocrinology diseases of the endocrine glands

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.