neoflavonoids as inhibitors of hiv-1 replication by targeting the tat and nf-κb pathways

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ID: 209343
2017
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Abstract
Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF-κB and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations <25 μM. The assays of these synthetic 4-phenylchromen-2-ones may aid in the investigation of some aspects of the anti-HIV activity of such compounds and could serve as a scaffold for designing better anti-HIV compounds, which may lead to a potential anti-HIV therapeutic drug.
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olmedo2017moleculesneoflavonoids Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dionisio A. Olmedo, José Luis López-Pérez, Esther del Olmo, Luis M. Bedoya, Rocío Sancho, José Alcamí, Eduardo Muñoz, Arturo San Feliciano, Mahabir P. Gupta
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Journal Journal of ethnopharmacology
Year 2017
DOI
10.3390/molecules22020321
URL
http://www.mdpi.com/1420-3049/22/2/321
Keywords
aids

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