neoflavonoids as inhibitors of hiv-1 replication by targeting the tat and nf-κb pathways
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ID: 209343
2017
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Abstract
Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2-one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF-κB and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations <25 μM. The assays of these synthetic 4-phenylchromen-2-ones may aid in the investigation of some aspects of the anti-HIV activity of such compounds and could serve as a scaffold for designing better anti-HIV compounds, which may lead to a potential anti-HIV therapeutic drug.
| Reference Key |
olmedo2017moleculesneoflavonoids
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|---|---|
| Authors | ;Dionisio A. Olmedo;José Luis López-Pérez;Esther del Olmo;Luis M. Bedoya;Rocío Sancho;José Alcamí;Eduardo Muñoz;Arturo San Feliciano;Mahabir P. Gupta |
| Journal | Journal of ethnopharmacology |
| Year | 2017 |
| DOI |
10.3390/molecules22020321
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| URL | |
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