biochemical and functional interactions of human papillomavirus proteins with polycomb group proteins
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ID: 208814
2013
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Abstract
The role of enzymes involved in polycomb repression of gene transcription has been studied extensively in human cancer. Polycomb repressive complexes mediate oncogene-induced senescence, a principal innate cell-intrinsic tumor suppressor pathway that thwarts expansion of cells that have suffered oncogenic hits. Infections with human cancer viruses including human papillomaviruses (HPVs) and Epstein-Barr virus can trigger oncogene-induced senescence, and the viruses have evolved strategies to abrogate this response in order to establish an infection and reprogram their host cells to establish a long-term persistent infection. As a consequence of inhibiting polycomb repression and evading oncogene induced-senescence, HPV infected cells have an altered epigenetic program as evidenced by aberrant homeobox gene expression. Similar alterations are frequently observed in non-virus associated human cancers and may be harnessed for diagnosis and therapy.
| Reference Key |
mclaughlin-drubin2013virusesbiochemical
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|---|---|
| Authors | ;Margaret E. McLaughlin-Drubin;Karl Munger |
| Journal | International journal of pharmaceutics |
| Year | 2013 |
| DOI |
10.3390/v5051231
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| URL | |
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