dna mismatch repair in eukaryotes and bacteria

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ID: 208707
2010
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Abstract
DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as well as sporadic tumors. To date, 2 types of MMRs are known: the human type and Escherichia coli type. The basic features of the former system are expected to be universal among the vast majority of organisms including most bacteria. Here, I review the molecular mechanisms of eukaryotic and bacterial MMR, emphasizing on the similarities between them.
Reference Key
fukui2010journaldna Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kenji Fukui
Journal gas separation \& purification
Year 2010
DOI
10.4061/2010/260512
URL
http://dx.doi.org/10.4061/2010/260512
Keywords
geneticsbiochemistry

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