understanding allergic asthma from allergen inhalation tests
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ID: 208300
2007
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Abstract
The allergen challenge has evolved, in less than 150 years, from a crude tool used to document the etiology of allergen-induced disease to a well-controlled tool used today to investigate the pathophysiology and pharmacotherapy of asthma. Highlights of the authors’ involvement with the allergen challenge include confirmation of the immunoglobulin E-dependence of the late asthmatic response, importance of (nonallergic) airway hyper-responsiveness as a determinant of the airway response to allergen, identification of allergen-induced increase in airway hyper-responsiveness, documentation of beta2-agonist-induced increase in airway response to allergen (including eosinophilic inflammation), advances in understanding the pathophysiology and kinetics of allergen-induced airway responses, and development of a muticentre clinical trial group devoted to using the allergen challenge for investigating promising new therapeutic strategies for asthma.
| Reference Key |
cockcroft2007canadianunderstanding
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|---|---|
| Authors | ;Donald W Cockcroft;Fredrick E Hargreave;Paul M O’Byrne;Louis-Philippe Boulet |
| Journal | religions |
| Year | 2007 |
| DOI |
10.1155/2007/753450
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| URL | |
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