the vital dye cdr10b labels the zebrafish mid-intestine and lumen
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2017
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Abstract
We describe the use of the fluorescent reporter compound CDr10b to label mid-intestinal structures in zebrafish larvae after simple immersion. CDr10b is deposited into the gut where it initially fills the lumen and is excreted. Using laser-mediated injury of the intestine, we show that CDr10b provides a useful readout of the integrity and repair of the epithelial cell barrier. In addition, CDr10b specifically labels the absorptive mid-intestine segment that is analogous to the mammalian small intestine. By perturbing retinoic acid signaling, which regulates the size of the mid-intestine segment, we show that CDr10b is a valuable tool to rapidly assess developmental malformations of the intestine in live animals.
| Reference Key |
sander2017moleculesthe
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|---|---|
| Authors | ;Veronika Sander;Shantanu Patke;Jung Y. Lee;Young-Tae Chang;Alan J. Davidson |
| Journal | Journal of ethnopharmacology |
| Year | 2017 |
| DOI |
10.3390/molecules22030454
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| URL | |
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