induction of th17 lymphocytes and treg cells by monocyte-derived dendritic cells in patients with rheumatoid arthritis and systemic lupus erythematosus
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2013
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Abstract
Dendritic cells (DCs) have a key role in the regulation of immune response. We herein explored, in patients with inflammatory diseases, the role of monocyte derived DC’s (mo-DCs) on the generation of Th17 and T regulatory (Treg) lymphocytes. Peripheral blood was obtained from thirty-five patients with rheumatoid arthritis (RA), twelve with systemic lupus erythematosus (SLE), and twenty healthy subjects. Mo-DCs were generated under standard (IL-4/GM-CSF) or tolerogenic (IL-4/GM-CSF plus recombinant P-selectin or PD-1 or IL-10) conditions, and their ability to induce Th17 and Treg lymphocytes was tested. We detected that mo-DCs from patients with RA showed an enhanced release of IL-6 and IL-23 as well as an increased capability to induce Th17 cells. Although mo-DCs from SLE patients also released high levels of IL-6/IL-23, it did not show an increased ability to induce Th17 lymphocytes. In addition, mo-DCs, from patients with RA and SLE generated under the engagement of PSGL-1, showed a defective capability to induce Foxp3+ Treg cells. A similar phenomenon was observed in SLE, when DC’s cells were generated under PDL-1 engagement. Our data indicate that DCs from patients with rheumatic inflammatory disease show an aberrant function that may have an important role in the pathogenesis of these conditions.
| Reference Key |
estrada-capetillo2013clinicalinduction
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|---|---|
| Authors | ;Lizbeth Estrada-Capetillo;Berenice Hernández-Castro;Adriana Monsiváis-Urenda;Crisol Alvarez-Quiroga;Esther Layseca-Espinosa;Carlos Abud-Mendoza;Lourdes Baranda;Ana Urzainqui;Francisco Sánchez-Madrid;Roberto González-Amaro |
| Journal | Applied Surface Science |
| Year | 2013 |
| DOI |
10.1155/2013/584303
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| URL | |
| Keywords |
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