The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies.

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ID: 20736
2019
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Abstract
Over 3000 candidate gene association studies have been performed to elucidate the genetic underpinnings of schizophrenia. However, a comprehensive evaluation of these studies' findings has not been undertaken since the decommissioning of the schizophrenia gene (SzGene) database in 2011. As such, we systematically identified and carried out random-effects meta-analyses for all polymorphisms with four or more independent studies in schizophrenia along with a series of expanded meta-analyses incorporating published and unpublished genome-wide association (GWA) study data. Based on 550 meta-analyses, 11 SNPs in eight linkage disequilibrium (LD) independent loci showed Bonferroni-significant associations with schizophrenia. Expanded meta-analyses identified an additional 10 SNPs, for a total of 21 Bonferroni-significant SNPs in 14 LD-independent loci. Three of these loci (MTHFR, DAOA, ARVCF) had never been implicated by a schizophrenia GWA study. In sum, the present study has provided a comprehensive summary of the current schizophrenia genetics knowledgebase and has made available all the collected data as a resource for the research community.
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liu2019thetranslational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liu, Chenxing;Kanazawa, Tetsufumi;Tian, Ye;Mohamed Saini, Suriati;Mancuso, Serafino;Mostaid, Md Shaki;Takahashi, Atsushi;Zhang, Dai;Zhang, Fuquan;Yu, Hao;Doo Shin, Hyoung;Sub Cheong, Hyun;Ikeda, Masashi;Kubo, Michiaki;Iwata, Nakao;Woo, Sung-Il;Yue, Weihua;Kamatani, Yoichiro;Shi, Yongyong;Li, Zhiqiang;Everall, Ian;Pantelis, Christos;Bousman, Chad;
Journal Translational Psychiatry
Year 2019
DOI
10.1038/s41398-019-0532-4
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