progranulin inhibits human t lymphocyte proliferation by inducing the formation of regulatory t lymphocytes
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2017
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Abstract
We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA. PGRN-mediated inhibition of T lymphocyte proliferation, as well as the induction of iTregs, was completely reversed by a TGF-β inhibitor or a Treg inhibitor. PGRN induced TGF-β secretion in the presence of PHA whereas it did not in the absence of PHA. Our findings indicate that PGRN suppresses T lymphocyte proliferation by enhancing the formation of iTregs from activated T lymphocytes in response to TGF-β.
| Reference Key |
kwack2017mediatorsprogranulin
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|---|---|
| Authors | ;Kyu Hwan Kwack;Hyeon-Woo Lee |
| Journal | polyhedron |
| Year | 2017 |
| DOI |
10.1155/2017/7682083
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| URL | |
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