how to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis – designing a prospective observational study in south africa

Clicks: 296
ID: 207303
2016
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #141 of 333 articles by views in chemical research in chinese universities

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 333 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes. Adherence to tuberculosis (TB) treatment is a public health concern. The main objective of this research is to develop a study design for evaluation of HRQOL and its association with medication adherence in TB in South Africa. Methodology: A conceptual framework for HRQOL in TB has been developed to identify patient-reported outcome (PRO) measures for HRQOL and adherence and to generate an endpoint model. Two generic (SF-12 and EQ-5D-5L), one disease-specific (St. George´s Respiratory Questionnaire (SGRQ)) and one condition-specific (Hospital Anxiety and Depression Scale (HADS)) measure for HRQOL and Morisky Medication Adherence Scale (MMAS) for adherence assessment were identified. All measures are applied in a longitudinal multicentre study at five data collection time points during standard TB treatment. Statistical analysis includes multivariable analysis. Change over time in the physical component score (PCS) of SF-12 is defined as primary endpoint. Sample size estimation based thereupon has led to a recruitment target of 96 patients. This study is on-going. Discussion: This is the first longitudinal study in South Africa which evaluates HRQOL and its association with medication adherence in TB in a comprehensive manner. Results will help to improve current treatment programmes and medication adherence and will support the identification of sustainable health innovations in TB, determining the value of new products, and supporting decision making with regard to health policy and pricing.
Reference Key
kastien-hilka2016frontiershow Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tanja Kastien-Hilka;Tanja Kastien-Hilka;Tanja Kastien-Hilka;Bernd Rosenkranz;Bernd Rosenkranz;Bryan Bennett;Edina Sinanovic;Matthias Schwenkglenks;Matthias Schwenkglenks;Matthias Schwenkglenks
Journal chemical research in chinese universities
Year 2016
DOI
10.3389/fphar.2016.00125
URL
http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00125/full
Keywords
tuberculosis south africa adherence study design pharmacology

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.