spike-timing dependent plasticity beyond synapse - pre- and post-synaptic plasticity of intrinsic neuronal excitability

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ID: 207112
2010
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Abstract
Long-lasting plasticity of synaptic transmission is classically thought to be the cellular substrate for information storage in the brain. Recent data indicate however that it is not the whole story. Persistent changes in the intrinsic neuronal excitability have been shown to occur in parallel to the induction of long-term synaptic modifications. This form of plasticity depends on the regulation of voltage-gated ion channels. Here we review the experimental evidence for plasticity of neuronal excitability induced at pre- or post-synaptic sites when long-term plasticity of synaptic transmission is induced with Spike-Timing-Dependent Plasticity (STDP) protocols. We describe the induction and expression mechanisms of the induced changes in excitability. Finally, the functional synergy between synaptic and non-synaptic plasticity and their spatial extent are discussed.
Reference Key
debanne2010frontiersspike-timing Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Dominique Debanne;Dominique Debanne;Mu-Ming Poo
Journal Diabetes
Year 2010
DOI
10.3389/fnsyn.2010.00021
URL
http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00021/full
Keywords
hippocampus plasticity stdp neuropsychiatry biological psychiatry

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