Antibacterial activity study of 1,2,4-triazole derivatives.

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ID: 2071
2019
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Ranked #48 of 406 articles by views in European journal of medicinal chemistry

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Abstract
Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. More effective antibacterial candidates might be obtained by the hybridization of 1,2,4-triazole with other antibacterial pharmacophores. This review summarizes the recent advances of 1,2,4-triazole derivatives as potential antibacterial compounds, and the structure-activity relationship is also discussed.
Reference Key
gao2019antibacterialeuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gao, Feng;Wang, Tengfei;Xiao, Jiaqi;Huang, Gang;
Journal European journal of medicinal chemistry
Year 2019
DOI
S0223-5234(19)30358-7
URL
Keywords Keywords not found

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