establishment of an induced pluripotent stem cell (ipsc) line from a 9-year old male with autism spectrum disorder (asd)
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2017
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Abstract
Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterized patient with autism spectrum disorder (ASD). The PMBCs were reprogrammed with the human OSKM transcription factors using the Sendai-virus delivery system. The pluripotency of transgene-free iPSCs was verified by immunocytochemistry for pluripotency markers and by spontaneous in vitro differentiation towards the 3 germ layers. Furthermore, the iPSC line showed normal karyotype. Our model might offer a good platform to study the pathomechanism of ASD, also for drug testing, early biomarker discovery and gene therapy studies.
| Reference Key |
varga2017stemestablishment
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|---|---|
| Authors | ;Eszter Varga;Csilla Nemes;István Bock;Zsuzsanna Táncos;Sára Berzsenyi;György Lévay;Viktor Román;Julianna Kobolák;András Dinnyés |
| Journal | journal of energy chemistry |
| Year | 2017 |
| DOI |
10.1016/j.scr.2017.03.013
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