preparation of novel nano-sized hydrogel microcapsules via layer-by-layer assembly as delivery vehicles for drugs onto hygiene paper

Herstellung neuartiger nanoskaliger Hydrogel-Mikrokapseln mittels Layer-by-Layer-Assemblierung als Wirkstoffträger auf Hygienepapier

preparasi mikrokapsul hidrogel berukuran nano baru melalui perakitan lapis demi lapis sebagai wahana penghantaran obat pada kertas higienis

preparação de novas microcápsulas de hidrogel de escala nanométrica via montagem camada por camada como veículos de liberação de fármacos em papel higiênico

通过层层自组装制备新型纳米级水凝胶微胶囊作为卫生用纸药物递送载体

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ID: 207019
2018
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Abstract
Hydrogel microcapsules are improved transplantation delivery vehicles for pharmaceuticals by effectively segregating the active ingredients from the surroundings and delivering them to a certain target site. Layer-by-layer (LbL) assembly is an attractive process to fabricate the nano-sized hydrogel microcapsules. In this study, nano-sized hydrogel microcapsules were prepared through LbL assembly using calcium carbonate nanoparticles (CaCO3 NPs) as the sacrificial inorganic template, sodium alginate (SA) and polyethyleneimine (PEI) as the shell materials. Ciprofloxacin was used to study the encapsulation and release properties of the hydrogel microcapsules. The hydrogel microcapsules were further adsorbed onto the paper to render antimicrobial properties. The results showed that the mean size of the CaCO3 template was reduced after dispersing into sodium n-dodecyl sulfate (SDS) solution under sonication. Transmission electron microscope (TEM) and atomic force microscope (AFM) revealed that some hydrogel microcapsules had a diameter under 200 nm, typical creases and collapses were found on the surface. The nano-sized PEI/SA hydrogel microcapsules showed high loading capacity of ciprofloxacin and a sustained release. PEI/SA hydrogel microcapsules rendered good antimicrobial properties onto the paper by the adsorption of hydrogel microcapsules, however, the mechanical properties of the hygiene paper were decreased.
Hydrogel-Mikrokapseln stellen verbesserte Verabreichungsvehikel für Pharmazeutika bei Transplantationen dar, indem sie die aktiven Wirkstoffe wirksam von der Umgebung isolieren und an einen bestimmten Zielort transportieren. Die Layer-by-Layer-(LbL)-Assemblierung ist ein vielversprechendes Verfahren zur Herstellung nanoskaliger Hydrogel-Mikrokapseln. In dieser Studie wurden nanoskalige Hydrogel-Mikrokapseln mittels LbL-Assemblierung unter Verwendung von Calciumcarbonat-Nanopartikeln (CaCO3-NPs) als anorganisches Opfertemplat sowie Natriumalginat (SA) und Polyethylenimin (PEI) als Hüllmaterialien hergestellt. Ciprofloxacin wurde eingesetzt, um die Verkapselungs- und Freisetzungseigenschaften der Hydrogel-Mikrokapseln zu untersuchen. Des Weiteren wurden die Hydrogel-Mikrokapseln auf Papier adsorbiert, um diesem antimikrobielle Eigenschaften zu verleihen. Die Ergebnisse zeigten, dass sich die mittlere Größe des CaCO3-Templats nach der Dispergierung in einer Natrium-n-dodecylsulfat-(SDS)-Lösung unter Ultraschallbehandlung verringerte. Mittels Transmissionselektronenmikroskopie (TEM) und Rasterkraftmikroskopie (AFM) konnte nachgewiesen werden, dass einige Hydrogel-Mikrokapseln einen Durchmesser von unter 200 nm aufwiesen und typische Faltenbildungen sowie Kollapse auf der Oberfläche zu beobachten waren. Die nanoskaligen PEI/SA-Hydrogel-Mikrokapseln zeigten eine hohe Beladungskapazität für Ciprofloxacin sowie eine verzögerte Freisetzung. Durch die Adsorption der PEI/SA-Hydrogel-Mikrokapseln wurden dem Papier gute antimikrobielle Eigenschaften verliehen; allerdings wurden die mechanischen Eigenschaften des Hygienepapiers verringert.
Mikrokapsul hidrogel merupakan wahana penghantaran transplantasi yang ditingkatkan untuk sediaan farmasi dengan memisahkan bahan aktif secara efektif dari lingkungan sekitar dan menghantarkannya ke situs target tertentu. Perakitan lapis demi lapis (*layer-by-layer*/LbL) merupakan proses yang menjanjikan untuk memfabrikasi mikrokapsul hidrogel berukuran nano. Dalam penelitian ini, mikrokapsul hidrogel berukuran nano dipreparasi melalui perakitan LbL menggunakan nanopartikel kalsium karbonat (NP CaCO3) sebagai templat anorganik sakrifisial, serta natrium alginat (SA) dan polietilenaimina (PEI) sebagai material cangkang. Siprofloksasin digunakan untuk mempelajari karakteristik enkapsulasi dan pelepasan dari mikrokapsul hidrogel tersebut. Mikrokapsul hidrogel kemudian diadsorpsikan ke atas kertas untuk memberikan sifat antimikroba. Hasil penelitian menunjukkan bahwa ukuran rata-rata templat CaCO3 berkurang setelah didispersikan ke dalam larutan natrium n-dodesil sulfat (SDS) di bawah perlakuan sonikasi. Mikroskop elektron transmisi (TEM) dan mikroskop gaya atom (AFM) mengungkapkan bahwa sebagian mikrokapsul hidrogel memiliki diameter di bawah 200 nm, serta lipatan dan kolaps tipikal ditemukan pada permukaannya. Mikrokapsul hidrogel PEI/SA berukuran nano menunjukkan kapasitas pemuatan siprofloksasin yang tinggi dan profil pelepasan yang berkelanjutan. Mikrokapsul hidrogel PEI/SA memberikan sifat antimikroba yang baik pada kertas melalui adsorpsi mikrokapsul hidrogel, namun sifat mekanis kertas higienis tersebut mengalami penurunan.
As microcápsulas de hidrogel são veículos aprimorados de liberação para transplante de produtos farmacêuticos, uma vez que segregam eficazmente os princípios ativos do meio circundante e os conduzem a um sítio-alvo específico. A montagem camada por camada (LbL, do inglês *layer-by-layer*) é um processo atrativo para a fabricação de microcápsulas nanométricas de hidrogel. Neste estudo, microcápsulas nanométricas de hidrogel foram preparadas por meio de montagem LbL utilizando nanopartículas de carbonato de cálcio (NPs de CaCO3) como molde inorgânico de sacrifício, e alginato de sódio (SA) e polietilenoimina (PEI) como materiais de invólucro. A ciprofloxacina foi utilizada para estudar as propriedades de encapsulamento e liberação das microcápsulas de hidrogel. As microcápsulas de hidrogel foram posteriormente adsorvidas no papel para conferir propriedades antimicrobianas. Os resultados demonstraram que o tamanho médio do molde de CaCO3 foi reduzido após a dispersão em solução de n-dodecil sulfato de sódio (SDS) sob sonicação. A microscopia eletrônica de transmissão (TEM) e a microscopia de força atômica (AFM) revelaram que algumas microcápsulas de hidrogel apresentavam diâmetro inferior a 200 nm, sendo observados dobras e colapsos típicos na superfície. As microcápsulas nanométricas de hidrogel de PEI/SA exibiram alta capacidade de incorporação de ciprofloxacina e uma liberação sustentada. As microcápsulas de hidrogel de PEI/SA conferiram boas propriedades antimicrobianas ao papel por meio de sua adsorção; no entanto, as propriedades mecânicas do papel higiênico foram reduzidas.
水凝胶微胶囊通过有效隔离活性成分与周围环境并将其递送至特定靶位点，成为一种改进的药物递送载体。层层自组装（LbL）技术是制备纳米级水凝胶微胶囊的一种极具吸引力的方法。本研究以碳酸钙纳米颗粒（CaCO3 NPs）为牺牲性无机模板，海藻酸钠（SA）和聚乙烯亚胺（PEI）为壳层材料，通过LbL自组装技术制备了纳米级水凝胶微胶囊。以环丙沙星为模型药物，研究了该水凝胶微胶囊的包封与释放性能。进一步将水凝胶微胶囊吸附于纸张上以赋予其抗菌性能。结果表明，在超声条件下分散于十二烷基硫酸钠（SDS）溶液中后，CaCO3模板的平均粒径减小。透射电子显微镜（TEM）和原子力显微镜（AFM）表征显示，部分水凝胶微胶囊的直径小于200 nm，且表面存在典型的褶皱和塌陷。纳米级PEI/SA水凝胶微胶囊表现出对环丙沙星的高负载能力和缓释性能。通过吸附水凝胶微胶囊赋予了纸张良好的抗菌性能，然而卫生纸的力学性能有所下降。
Reference Key
li2018polymerspreparation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Junrong Li;Jing Zou;Huining Xiao;Beihai He;Xiaobang Hou;Liying Qian
Journal Journal of Fluorescence
Year 2018
DOI
10.3390/polym10030335
URL
http://www.mdpi.com/2073-4360/10/3/335
Keywords
sodium alginate polydopamine layer-by-layer assembly magnetic nanocomposites molecularly imprinted mesoporous silica

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