1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents.

Clicks: 355
ID: 2070
2019
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Ranked #49 of 406 articles by views in European journal of medicinal chemistry

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Abstract
Bacterial infections, caused predominately by Gram-positive and Gram-negative organisms, are proliferation of harmful strains of bacteria on or inside the body. Hospital-acquired and community-acquired bacterial infections have already put a heavy burden on the global health system. Antibiotics can disrupt the processes necessary for bacterial cell growth and proliferation, are effective weapons to fight against bacterial infections. However, the overuse and misuse of antibiotics have led to a rise in antibiotic resistance, creating an urgent need to develop novel antibiotics. 1,2,4-Triazole-quinoline/quinolone hybrids possess a broad spectrum of chemotherapeutic properties, also demonstrated promising anti-bacterial activities against both drug-sensitive and drug-resistant bacteria. This review covers the recent advances of 1,2,4-triazole-quinoline/quinolone hybrids as potential anti-bacterial agents. The structure-activity relationship (SAR) is also discussed for further rational development of 1,2,4-triazole hybrids higher potency against both drug-sensitive and drug-resistant pathogens.
Reference Key
zhang2019124triazolequinolinequinoloneeuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Jingyu;Wang, Su;Ba, Yanyan;Xu, Zhi;
Journal European journal of medicinal chemistry
Year 2019
DOI
S0223-5234(19)30348-4
URL
Keywords Keywords not found

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