in vivo effects of mid-myocardial pacing on transmural dispersion of repolarization and conduction in canines
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ID: 206898
2015
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Abstract
Objective: In our previous in vitro study mid-myocardial relative to epicardial pacing decreased transmural dispersion of depolarization (TDR) and prevented ventricular arrhythmia. We therefore hypothesized that in vivo mid-myocardial pacing in canines has a similar effect.
Methods and results: Using custom-made electrodes, monophasic action potentials were simultaneously recorded in vivo from left ventricular epicardial (Epi), mid-myocardial (Mid) and endocardial (Endo) layers of canines (n = 12). TDR was significantly increased at Epi (44.6 ± 6. 4 ms; 14.2 ± 5.1 ms; and 13.8 ± 5.4 ms for Epi, Mid and Endo pacing, respectively; P < 0.001), and similarly at Mid and Endo pacing (P = 0.855). This result was reproducible after ibutilide administration (n = 12). TDR was augmented at each layer pacing and significantly increased at Epi (78.1 ± 15.9 ms; 46.8 ± 16.0 ms; and 46.5 ± 15.2 ms for Epi, Mid, and Endo pacing, respectively; P < 0.001), but was similar at Endo and Mid pacing (P = 0.965). TDR at 3 cm from left ventricular apex pacing site was similar between Mid and Endo pacing, and still significantly increased at Epi pacing. At 3 cm distance, the first activation myocardium was still the epicardium at Epi, while sequence transformed from mid-myocardium to endocardium at Mid pacing.
Conclusion: Mid as compared to Epi pacing significantly decreases TDR and remains this advantage on the distant myocardium away from the pacing site.
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| Reference Key |
zhao2015internationalin
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|---|---|
| Authors | ;Liang Zhao;Tao Xu;Hao Wang;Peng Liu;Jiayou Zhang;Congxin Huang;Dening Liao |
| Journal | international microbiology : the official journal of the spanish society for microbiology |
| Year | 2015 |
| DOI |
10.1016/j.ijcha.2015.01.003
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| URL | |
| Keywords | Keywords not found |
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