entamoeba histolytica: adhesins and lectins in the trophozoite surface

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ID: 206836
2015
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Abstract
Entamoeba histolytica is the causative agent of amebiasis in humans and is responsible for 100,000 deaths annually, making it the third leading cause of death due to a protozoan parasite. Pathogenesis appears to result from the potent cytotoxic activity of the parasite, which kills host cells within minutes. Although the mechanism is unknown, it is well established to be contact-dependent. The life cycle of the parasite alternates with two forms: the resistant cyst and the invasive trophozoite. The adhesive interactions between the parasite and surface glycoconjugates of host cells, as well as those lining the epithelia, are determinants for invasion of human tissues, for its cytotoxic activity, and finally for the outcome of the disease. In this review we present an overview of the information available on the amebic lectins and adhesins that are responsible of those adhesive interactions and we also refer to their effect on the host immune response. Finally, we present some concluding remarks and perspectives in the field.
Reference Key
garca2015moleculesentamoeba Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Magdalena Aguirre García;Laila Gutiérrez-Kobeh;Rosario López Vancell
Journal Journal of ethnopharmacology
Year 2015
DOI
10.3390/molecules20022802
URL
http://www.mdpi.com/1420-3049/20/2/2802
Keywords
entamoeba histolytica adhesins cytotoxicityorganic chemistry

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