lack of association between gastric cancer and hopq alleles in helicobacter pylori
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2016
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Abstract
Helicobacter pylori use a number of mechanisms to survive in the stomach
lumen. The presence of these bacteria in the stomach can lead to gastritis
and reduction in stomach acid production. Acute inflammation can directly
damage to the peripheral cells that are responsible for the secretion of
acid. The risk of developing gastric carcinoma is associated to heterogeneity
of Helicobacter pylori virulence factors (such as cagA). The HopQ is one of
the outer membrane proteins involved in bacterial adherence to gastric mucosa
and has been suggested to also play a role in the virulence of H. pylori.
This gene has been shown in two types. The purpose of the current study was
to investigate the association between different H. pylori virulence hopQ
alleles (types I and II) and patients with gastroduodenal disorders. For this
purpose 58 stomach biopsies the of patients with gastric cancer and 100
saliva samples from healthy individuals were collected. Then genomic DNA was
purified and PCR for was done for desired genes via specific primers. The H.
pylori infections were diagnosed by PCR for GlmM gene. Then frequencies of
hopQI+, hopQII+ and hopQI+ hopQII+ genotypes were determined in H. pylori
infected cases. Statistical analysis showed that there were not significant
differences between healthy and diseased ones for genotypes hopQI+, hopQII+
and hopQI+ hopQII+.
| Reference Key |
elham2016genetikalack
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|---|---|
| Authors | ;Kazemi Elham;Kahrizi Danial |
| Journal | Chemical biology & drug design |
| Year | 2016 |
| DOI |
10.2298/GENSR1603893K
|
| URL | |
| Keywords |
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