inhibitory effects of verrucarin a on tunicamycin-induced er stress in fao rat liver cells
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ID: 206121
2015
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Abstract
Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover, the compound decreased the expression of GRP78, CHOP, XBP-1, and suppressed XBP-1, and reduced phosphorylation of IRE1α in FaO rat liver cells. This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells.
| Reference Key |
bae2015moleculesinhibitory
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|---|---|
| Authors | ;Eun Young Bae;Seung Woong Lee;Sin Seong;Wonjun Cho;Jong Seog Ahn;Hyun-Sug Cho |
| Journal | Journal of ethnopharmacology |
| Year | 2015 |
| DOI |
10.3390/molecules20058988
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| URL | |
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