inhibitory effects of verrucarin a on tunicamycin-induced er stress in fao rat liver cells

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ID: 206121
2015
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Abstract
Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover, the compound decreased the expression of GRP78, CHOP, XBP-1, and suppressed XBP-1, and reduced phosphorylation of IRE1α in FaO rat liver cells. This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells.
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bae2015moleculesinhibitory Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Eun Young Bae, Seung Woong Lee, Sin Seong, Wonjun Cho, Jong Seog Ahn, Hyun-Sug Cho
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Journal Journal of ethnopharmacology
Year 2015
DOI
10.3390/molecules20058988
URL
http://www.mdpi.com/1420-3049/20/5/8988
Keywords
er stress tunicamycin

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