evolutionary and expression analysis of mir-#-5p and mir-#-3p at the mirnas/isomirs levels

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ID: 205608
2015
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Abstract
We mainly discussed miR-#-5p and miR-#-3p under three aspects: (1) primary evolutionary analysis of human miRNAs; (2) evolutionary analysis of miRNAs from different arms across the typical 10 vertebrates; (3) expression pattern analysis of miRNAs at the miRNA/isomiR levels using public small RNA sequencing datasets. We found that no bias can be detected between the numbers of 5p-miRNA and 3p-miRNA, while miRNAs from miR-#-5p and miR-#-3p show variable nucleotide compositions. IsomiR expression profiles from the two arms are always stable, but isomiR expressions in diseased samples are prone to show larger degree of dispersion. miR-#-5p and miR-#-3p have relative independent evolution/expression patterns and datasets of target mRNAs, which might also contribute to the phenomena of arm selection and/or arm switching. Simultaneously, miRNA/isomiR expression profiles may be regulated via arm selection and/or arm switching, and the dynamic miRNAome and isomiRome will adapt to functional and/or evolutionary pressures. A comprehensive analysis and further experimental study at the miRNA/isomiR levels are quite necessary for miRNA study.
Reference Key
guo2015biomedevolutionary Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li Guo, Jiafeng Yu, Hao Yu, Yang Zhao, Shujie Chen, Changqing Xu, Feng Chen
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Journal spectrochimica acta - part a: molecular and biomolecular spectroscopy
Year 2015
DOI
10.1155/2015/168358
URL
http://dx.doi.org/10.1155/2015/168358
Keywords
Medicine

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