lithothamnion muelleri controls inflammatory responses, target organ injury and lethality associated with graft-versus-host disease in mice
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2013
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Abstract
Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which is a member of a group of algae with anti-inflammatory, antitumor, and immunomodulatory properties. The present study evaluated the effects of treatment with Lithothamnion muelleri extract (LM) in a model of acute graft-versus-host disease (GVHD), using a model of adoptive splenocyte transfer from C57BL/6 donors into B6D2F1 recipient mice. Mice treated with LM showed reduced clinical signs of disease and mortality when compared with untreated mice. LM-treated mice had reduced tissue injury, less bacterial translocation, and decreased levels of proinflammatory cytokines and chemokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5)). The polysaccharide-rich fraction derived from LM could inhibit leukocyte rolling and adhesion in intestinal venules, as assessed by intravital microscopy. LM treatment did not impair the beneficial effects of graft-versus-leukaemia (GVL). Altogether, our studies suggest that treatment with Lithothamnion muelleri has a potential therapeutic application in GVHD treatment.
| Reference Key |
teixeira2013marinelithothamnion
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| Authors | ;Mauro M. Teixeira;Marina G. M. Castor;Fernão C. Braga;Danielle G. Souza;Rosa M. E. Arantes;Carolina B. Resende;Priscila T. T. Bernardes;Barbara M. Rezende;Vanessa Pinho |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2013 |
| DOI |
10.3390/md11072595
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| URL | |
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