does intensive glucose control prevent cognitive decline in diabetes? a meta-analysis
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2015
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Abstract
Diabetes mellitus is associated with cognitive decline and impaired performance in cognitive function tests among type 1 and type 2 diabetics. Even though the use of tight glucose control has been limited by a reported higher mortality, few reports have assessed the impact of treatment intensity on cognitive function. We conducted a meta-analysis to evaluate if an intensive glucose control in diabetes improves cognitive function, in comparison to standard therapy. We included 7 studies that included type 1 or type 2 diabetics and used standardized tests to evaluate various cognitive function domains. Standardized mean differences (SMDs) were calculated for each domain. We found that type 1 diabetics get no cognitive benefit from a tight glucose control, whereas type 2 diabetics get some benefit on processing speed and executive domains but had worse performances in the memory and attention domains, along with a higher incidence of mortality when using intensive glucose control regimes.
| Reference Key |
peaherrera-oviedo2015internationaldoes
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| Authors | ;Carlos Peñaherrera-Oviedo;Daniel Moreno-Zambrano;Michael Palacios;María Carolina Duarte-Martinez;Carlos Cevallos;Ximena Gamboa;María Beatriz Jurado;Leonardo Tamariz;Ana Palacio;Rocío Santibañez |
| Journal | international journal of life sciences and biotechnology |
| Year | 2015 |
| DOI |
10.1155/2015/680104
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