in vitro and in vivo evaluation of electrospun pcl/pmma fibrous scaffolds for bone regeneration

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ID: 205338
2013
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Abstract
Scaffolds were fabricated by electrospinning using polycaprolactone (PCL) blended with poly(methyl methacrylate) (PMMA) in ratios of 10/0, 7/3, 5/5 and 3/7. The PCL/PMMA ratio affected the fiber diameter, contact angle, tensile strength and biological in vitro and in vivo properties of the scaffolds, and the 7/3 ratio resulted in a higher mechanical strength than 5/5 and 3/7. In vitro cytotoxicity and proliferation of MG-63 osteoblast cells on these blended scaffolds were examined by MTT assay, and it was found that PCL/PMMA blends are suitable for osteoblast cell proliferation. Confocal images and expression of proliferating cell nuclear antigen confirmed the good proliferation and expression of cells on the 7/3 PCL/PMMA fibrous scaffolds. In vivo bone formation was examined using rat models, and bone formation was observed on the 7/3 PCL/PMMA scaffold within 2 months. In vitro and in vivo results suggest that 7/3 PCL/PMMA scaffolds can be used for bone tissue regeneration.
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lee2013sciencein Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors So-Ra Son, Nguyen-Thuy Ba Linh, Hun-Mo Yang and Byong-Taek Lee
Journal ieee control systems letters
Year 2013
DOI
DOI not found
URL
http://dx.doi.org/10.1088/1468-6996/14/1/015009
Keywords
materials of engineering and construction mechanics of materialsbiotechnology

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