the role of macrophages in tumor development

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ID: 204105
2005
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Abstract
Macrophages constitute a large proportion of the immune cell infiltrate, which is present in many tumors. Activation state of macrophages is greatly influenced by their environment, leading to different macrophage subsets with diverse functions. Although previously regarded as potent immune cells that are capable of destroying tumor cells, recent literature focuses on the ability of macrophages to promote tumor development due to secretion of mediators, like growth and angiogenic factors. It is now becoming increasingly clear that a complicated synergistic relationship exists between macrophages and malignant cells whereby tumor cells can affect macrophage phenotype, and vice versa. As such, macrophages and their contribution in cancer development are currently subject of debate.
Reference Key
bij2005cellularthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Gerben J. van der Bij;Steven J. Oosterling;Sybren Meijer;Robert H. J. Beelen;Marjolein van Egmond
Journal journal of the serbian chemical society
Year 2005
DOI
10.1155/2005/719412
URL
http://dx.doi.org/10.1155/2005/719412
Keywords
neoplasms Oncology including cancer and carcinogenscytology tumors

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