what is trophoblast? a combination of criteria define human first-trimester trophoblast

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ID: 204096
2016
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Ranked #90 of 101 articles by views in nature reviews gastroenterology & hepatology

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Abstract
Controversy surrounds reports describing the derivation of human trophoblast cells from placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers that define cells as belonging to the trophoblast lineage. We have selected criteria that are characteristic of primary first-trimester trophoblast: a set of protein markers, HLA class I profile, methylation of ELF5, and expression of microRNAs (miRNAs) from the chromosome 19 miRNA cluster (C19MC). We tested these criteria on cells previously reported to show some phenotypic characteristics of trophoblast: bone morphogenetic protein (BMP)-treated human ESC and 2102Ep, an embryonal carcinoma cell line. Both cell types only show some, but not all, of the four trophoblast criteria. Thus, BMP-treated human ESC have not fully differentiated to trophoblast. Our study identifies a robust panel, including both protein and non-protein-coding markers that, in combination, can be used to reliably define cells as characteristic of early trophoblast.
Reference Key
lee2016stemwhat Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Cheryl Q.E. Lee;Lucy Gardner;Margherita Turco;Nancy Zhao;Matthew J. Murray;Nicholas Coleman;Janet Rossant;Myriam Hemberger;Ashley Moffett
Journal nature reviews gastroenterology & hepatology
Year 2016
DOI
10.1016/j.stemcr.2016.01.006
URL
http://www.sciencedirect.com/science/article/pii/S2213671116000230
Keywords
medicine (general)biology (general)

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