effect of putrescine on intensity of lipid peroxidation in rats’ brain with cholestasis
Clicks: 254
ID: 204069
2006
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Popular Article
30.0
/100
254 views
25 readers
AI Quality Assessment
Not analyzed
Readership in this journal
PopularRanked #19 of 67 articles by views in İşletme araştırmaları dergisi
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Encephalopathy in cholestasis results from accumulation of unconjugated bilirubin (UCB) and hydrophobic bile acids (BA). Toxic BA and UCB induces neurotoxicity (apoptosis of neurons). Putrescine, spermidine and spermine are endogenous polyamines essential for cellular growth, regeneration and differen-tiation. Beneficial effects of putrescine in CNS injury have been attributed to anti-apoptotic ant anti-oxidant properties.The aim of the study was to examine the effect of putrescine at the level of lipid peroxidation in cholestatic brain injury.Wistar rats were divided into 5 groups: I-control, II-sham operated rats, III-treated only with putrescine, IV-bile duct ligated (BDL) rats, V-BDL rats treated with putrescine (150mg/kg BW ip.). The animals were sacrificed after the 9 -day treatment.Administration of putrescine in BDL rats reduces concentration of blood plasma UCB and BA (29.2±3.3 vs. 43.6±5.9 μmol/l and 11.4±0.8 vs. 22.8±2.6 μmol/l; p < 0.001). The lipid peroxidation (MDA) was increased in brain of BDL rats (4.98±0.54 vs. sham operated rats 3.99±0.32 nmol/mg prot; p < 0.001). Putrescine decreased MDA level in brain of V group vs. IV group rats (2.25±0.42 vs. 4.98±0.54 nmol/mg p; p < 0.001). The amplification of cerebral activity of polyamine oxidase (PAO) in BDL rats (1.25±0.09 vs. sham operated rats 0.81±0.09 U/mg prot; p < 0.001), resulted in high local concentrations of 3-acetamidopropanol and H2O2 which lead to oxidative stress and cell death. Administration of putrescine of BDL rats, decreased activity of cerebral PAO compared with BDL rats (1.02±0.07 vs. 1.25±0.09 U/mg prot; p < 0.001).Administration of putrescine in BDL rats results in normalization of cerebral oxidative stress and has protective role after the CNS injury in cholestasis.
| Reference Key |
radic2006actaeffect
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Stojan Radic;Dusica Pavlovic;Boris Djindjic;Gordana Kocic;Jelenka Nikolic;Gordana Bjelakovic;Dusan Sokolovic;Jelena Basic;Marko Jovic;Dimitros Koutsonanos |
| Journal | İşletme araştırmaları dergisi |
| Year | 2006 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.