A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.

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2019
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Abstract
Embryonal tumors with multilayered rosettes (ETMRs) are highly lethal infant brain cancers with characteristic amplification of Chr19q13.41 miRNA cluster (C19MC) and enrichment of pluripotency factor LIN28A. Here we investigated C19MC oncogenic mechanisms and discovered a C19MC-LIN28A-MYCN circuit fueled by multiple complex regulatory loops including an MYCN core transcriptional network and super-enhancers resulting from long-range MYCN DNA interactions and C19MC gene fusions. Our data show that this powerful oncogenic circuit, which entraps an early neural lineage network, is potently abrogated by bromodomain inhibitor JQ1, leading to ETMR cell death.
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sinchan2019acancer Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Sin-Chan, Patrick;Mumal, Iqra;Suwal, Tannu;Ho, Ben;Fan, Xiaolian;Singh, Irtisha;Du, Yuchen;Lu, Mei;Patel, Neilket;Torchia, Jonathon;Popovski, Dean;Fouladi, Maryam;Guilhamon, Paul;Hansford, Jordan R;Leary, Sarah;Hoffman, Lindsey M;Mulcahy Levy, Jean M;Lassaletta, Alvaro;Solano-Paez, Palma;Rivas, Eloy;Reddy, Alyssa;Gillespie, G Yancey;Gupta, Nalin;Van Meter, Timothy E;Nakamura, Hideo;Wong, Tai-Tong;Ra, Young-Shin;Kim, Seung-Ki;Massimi, Luca;Grundy, Richard G;Fangusaro, Jason;Johnston, Donna;Chan, Jennifer;Lafay-Cousin, Lucie;Hwang, Eugene I;Wang, Yin;Catchpoole, Daniel;Michaud, Jean;Ellezam, Benjamin;Ramanujachar, Ramya;Lindsay, Holly;Taylor, Michael D;Hawkins, Cynthia E;Bouffet, Eric;Jabado, Nada;Singh, Sheila K;Kleinman, Claudia L;Barsyte-Lovejoy, Dalia;Li, Xiao-Nan;Dirks, Peter B;Lin, Charles Y;Mack, Stephen C;Rich, Jeremy N;Huang, Annie;
Journal cancer cell
Year 2019
DOI
S1535-6108(19)30293-4
URL
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