avaliação das condições de estocagem de vacinas vivas, atenuadas contra o sarampo, em postos de vacinação credenciados e em centros de saúde do estado de são paulo (brasil) an assessment of the storage conditions of live, attenuated vaccines against measles, in authorized vaccination centers and in health services in s. paulo state (brazil)
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1985
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Abstract
Para avaliar as condições de estocagem de vacinas vivas, atenuadas contra o sarampo, da rede de vacinação do Estado de São Paulo (Brasil), foram visitados 71 Postos de Vacinação Credenciados particulares (PVC), assim como 117 Centros de Saúde oficiais (CS), sobre os quais interessava saber a respeito da qualidade da estocagem a frio. Os parâmetros adotados foram: a) temperatura das geladeiras de uso (+2 a +8°C) e de estoque (+ 8°C); b) validade do produto; c) título das vacinas conservadas nestas geladeiras, avaliado pela inoculação de diluições das amostras de vacinas em células Vero; d) proteção à luz. Dos CS pesquisados, 85,33% apresentaram geladeiras com temperatura de acordo com a recomendada e 100% das vacinas neles estocadas com título e validade satisfatórios. Nos PVC foram encontrados, com maior freqüência, lotes de vacina fora do prazo de validade (14,49%), com títulos abaixo do mínimo requerido (3,53%) e geladeiras de uso e de estoque com temperaturas inadequadas (33,80%). Necessário se faz que as condições de estocagem das vacinas contra o sarampo (temperatura e proteção à luz), prevalentes no momento, sejam melhoradas e que as bulas passem a acompanhar o produto a eles entregue, para que os responsáveis pela vacinação obedeçam as recomendações do laboratório produtor com relação às condições de estocagem, validade e administração do imunobiológico, uma vez que a pesquisa revelou que estas não são observadas com o rigor necessário.
In the State of S. Paulo, Brazil, health centers sponsored by the State, as well as private health services, located in throughout large districts, are in charge of the vaccination against the various diseases affecting children, including measles. In the present study three of the above mentioned districts, covering 385 State Health Centers (SHC) and 200 Private Health Services (PHS) were surveyed. From these totals 117 SHC and 71 PHS were chosen for the evaluation of: a) quality of the existing cold chain for measles vaccine storage (temperatura); b) vaccine titer; c) validity; d) protection from light. Of the SHC inspected, 85.33% kept vaccines at the recommended temperature, 100% presented vaccines with titers above the minimum required and within expiration date. Deficiency relating to protection from light, was found in 83.06%. Inspection of the PHS revealed that whereas 66.20% kept vaccine within the right temperature range, 76.06% did not protect them against light, only 96.47% had vaccines with potency above the level required and only 85.51%, observed the expiration date. The study led to the conclusion that in the State of S. Paulo, measles vaccines are better stored in the State Health Centers than in the Private Health Services surveyed indicating that the slight preference that parents show towards having their children vaccinated in PHS is not justified. It was suggested that some conditions of measles vaccine storage montly, temperature and protection from light should be improved and that instruction leaflets must always accompany immunobiological materials distributed to all health centers, to be consulted when doubts about the proper storage and administration of these vaccines arise.
In the State of S. Paulo, Brazil, health centers sponsored by the State, as well as private health services, located in throughout large districts, are in charge of the vaccination against the various diseases affecting children, including measles. In the present study three of the above mentioned districts, covering 385 State Health Centers (SHC) and 200 Private Health Services (PHS) were surveyed. From these totals 117 SHC and 71 PHS were chosen for the evaluation of: a) quality of the existing cold chain for measles vaccine storage (temperatura); b) vaccine titer; c) validity; d) protection from light. Of the SHC inspected, 85.33% kept vaccines at the recommended temperature, 100% presented vaccines with titers above the minimum required and within expiration date. Deficiency relating to protection from light, was found in 83.06%. Inspection of the PHS revealed that whereas 66.20% kept vaccine within the right temperature range, 76.06% did not protect them against light, only 96.47% had vaccines with potency above the level required and only 85.51%, observed the expiration date. The study led to the conclusion that in the State of S. Paulo, measles vaccines are better stored in the State Health Centers than in the Private Health Services surveyed indicating that the slight preference that parents show towards having their children vaccinated in PHS is not justified. It was suggested that some conditions of measles vaccine storage montly, temperature and protection from light should be improved and that instruction leaflets must always accompany immunobiological materials distributed to all health centers, to be consulted when doubts about the proper storage and administration of these vaccines arise.
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| Authors | ;Inácio França Mendes;Michel Marie Pral;Cosue Miyaki;Neuza Maria Frazatti Gallina;Vera Lucia Petricevich;Francisco Liauw Woe Fang;Hiroko Nakahata Tuchiya;Tuyoshi Ninomya;Edda de Rizzo |
| Journal | proceedings - 2016 3rd international conference on information technology, computer, and electrical engineering, icitacee 2016 |
| Year | 1985 |
| DOI |
10.1590/S0034-89101985000500008
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