effect of s-prg eluate on biofilm formation and enzyme activity of oral bacteria
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2012
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Abstract
Recently, the antibacterial activity of a composite resin containing prereacted glass ionomer (S-PRG) filler was revealed. We examined the effect of an S-PRG eluate on various biologic activities of Streptococcus mutans and Porphyromonas gingivalis. Adherence ability of S. mutans was evaluated by microtiter plate assay; protease and gelatinase activities of P. gingivalis were examined by synthetic substrate hydrolysis and gelatin film spot assay, respectively. Coaggregation of P. gingivalis with Fusobacterium nucleatum was also examined. S-PRG eluate was found to suppress streptococcal adherence. S-PRG eluate inhibited the protease and gelatinase activities of P. gingivalis and the coaggregation between P. gingivalis and F. nucleatum. These results indicate that S-PRG eluate suppresses streptococcal adherence and inhibits the protease and coaggregation activities of P. gingivalis. These findings may prompt research into novel strategies for preventing caries and periodontitis.
| Reference Key |
yoneda2012internationaleffect
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|---|---|
| Authors | ;Masahiro Yoneda;Nao Suzuki;Yosuke Masuo;Akie Fujimoto;Kosaku Iha;Kazuhiko Yamada;Tomoyuki Iwamoto;Takao Hirofuji |
| Journal | Bulletin of experimental biology and medicine |
| Year | 2012 |
| DOI |
10.1155/2012/814913
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