synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-plasmodium falciparum agents
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2014
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Abstract
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.
| Reference Key |
gil2014moleculessynthesis,
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|---|---|
| Authors | ;Ana Gil;Adriana Pabón;Silvia Galiano;Asunción Burguete;Silvia Pérez-Silanes;Eric Deharo;Antonio Monge;Ignacio Aldana |
| Journal | Journal of ethnopharmacology |
| Year | 2014 |
| DOI |
10.3390/molecules19022166
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| URL | |
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