maturation and emigration of single-positive thymocytes

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ID: 203380
2013
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Abstract
T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed.
Reference Key
xu2013clinicalmaturation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xi Xu;Shusong Zhang;Pingping Li;Jin Lu;Qun Xuan;Qing Ge
Journal Applied Surface Science
Year 2013
DOI
10.1155/2013/282870
URL
http://dx.doi.org/10.1155/2013/282870
Keywords
immunologic diseases allergy

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