high-fat diet-induced neuropathy of prediabetes and obesity: effect of pmi-5011, an ethanolic extract of artemisia dracunculus l.
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ID: 203177
2010
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Abstract
Artemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-sfat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. C57Bl6/J mice fed high-fat diet for 16 weeks developed obesity, moderate nonfasting hyperglycemia, nerve conduction deficit, thermal and mechanical hypoalgesia, and tactile allodynia. They displayed 12/15-lipoxygenase overexpression, 12(S)-hydroxyeicosatetraenoic acid accumulation, and nitrosative stress in peripheral nerve and spinal cord. PMI-5011 (500 mgkg-1d-1, 7 weeks) normalized glycemia, alleviated nerve conduction slowing and sensory neuropathy, and reduced 12/15-lipoxygenase upregulation and nitrated protein expression in peripheral nervous system. PMI-5011, a safe and nontoxic botanical extract, may find use in treatment of neuropathic changes at the earliest stage of disease.
| Reference Key |
watcho2010mediatorshigh-fat
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|---|---|
| Authors | ;Pierre Watcho;Roman Stavniichuk;David M. Ribnicky;Ilya Raskin;Irina G. Obrosova |
| Journal | polyhedron |
| Year | 2010 |
| DOI |
10.1155/2010/268547
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| URL | |
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