valproate induced hyperammonemic encephalopathy treated by haemodialysis

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ID: 203161
2017
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Abstract
Valproate (VPA)-induced hyperammonemic encephalopathy is an unusual, but serious, adverse effect of divalproex sodium (DVPX) treatment and if untreated can lead to raised intracranial pressure, seizures, coma, and eventually death. It can, however, be reversed if an early diagnosis is made. It is therefore extremely important to recognize it and discontinue DVPX treatment. Our patient developed sudden deterioration of sensorium, drowsiness, lethargy, and later severe comatose state after few days of starting DVPX with high levels of serum ammonia despite therapeutic levels of VPA and normal liver function test. He responded to hemodialysis, cerebral decongestants, and other intensive supportive measures.
Reference Key
chauhan2017industrialvalproate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Vinay Singh Chauhan;Siddarth Dixit;Sunil Goyal;Sudip Azad
Journal trends in neurosciences
Year 2017
DOI
10.4103/ipj.ipj_37_16
URL
http://www.industrialpsychiatry.org/article.asp?issn=0972-6748;year=2017;volume=26;issue=1;spage=99;epage=102;aulast=Chauhan
Keywords
encephalopathy

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