induction murine models of chronic fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?
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2015
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Abstract
To investigate whether Brucella abortus (BA) antigen injections lead to anemia, and to establish an appropriate Chronic Fatigue Syndrome (CFS) animal model by BA injections, 6 repeated injections of BA antigen were fulfilled every 2 weeks. At a high dose of 1∗1010 particles/mouse, anemia was induced within 2 weeks and then recovered a lot at the end of the research, while at a moderate dose of 1∗108 (3 injections) shifting to 1∗109/mouse (3 injections) anemia was absent. In both groups running wheel activity remained very low even 6 weeks after the last injection.
| Reference Key |
moriya2015biomedinduction
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|---|---|
| Authors | ;Junji Moriya;Qiang He;Hiroaki Uenishi;Sumiyo Akazawa;Jun-ichi Yamakawa;Junji Kobayashi;Yasuhito Ishigaki |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2015 |
| DOI |
10.1155/2015/191489
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| URL | |
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