effects of cannabinoid exposure during adolescence on the conditioned rewarding effects of win 55212-2 and cocaine in mice: influence of the novelty-seeking trait

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ID: 202861
2016
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Abstract
Adolescent exposure to cannabinoids enhances the behavioural effects of cocaine, and high novelty-seeking trait predicts greater sensitivity to the conditioned place preference (CPP) induced by this drug. Our aim was to evaluate the influence of novelty-seeking on the effects of adolescent cannabinoid exposure. Adolescent male mice were classified as high or low novelty seekers (HNS and LNS) in the hole-board test. First, we evaluated the CPP induced by the cannabinoid agonist WIN 55212-2 (0.05 and 0.075 mg/kg, i.p.) in HNS and LNS mice. Then, HNS and LNS mice were pretreated i.p. with vehicle, WIN 55212-2 (0.1 mg/kg), or cannabinoid antagonist rimonabant (1 mg/kg) and were subsequently conditioned with WIN 55212-2 (0.05 mg/kg, i.p.) or cocaine (1 or 6 mg/kg, i.p.). Only HNS mice conditioned with the 0.075 mg/kg dose acquired CPP with WIN 55212-2. Adolescent exposure to this cannabinoid agonist increased the rewarding effects of 1 mg/kg of cocaine in both HNS and LNS mice, and in HNS mice it also increased the reinstating effect of a low dose of cocaine. Our results endorse a role for individual differences such as a higher propensity for sensation-seeking in the development of addiction.
Reference Key
rodrguez-arias2016neuraleffects Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;M. Rodríguez-Arias;C. Roger-Sánchez;I. Vilanova;N. Revert;C. Manzanedo;J. Miñarro;M. A. Aguilar
Journal tetrahedron
Year 2016
DOI
10.1155/2016/6481862
URL
http://dx.doi.org/10.1155/2016/6481862
Keywords
neurosciences neuropsychiatry biological psychiatry

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