myeloprotective efficiency of combination of pyrimidine and 3-hydroxypyridine derivatives in experimental antineoplastic chemotherapy
Clicks: 232
ID: 202727
2015
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
30.0
/100
232 views
29 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #31 of 121 articles by views in respirology (carlton, vic)
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 121 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The aim of the study is comparative assessment of the influence of separated and combined use of pyrimidine and 3-hydroxypyridine derivatives — xymedon and mexidol on the bone marrow hemopoiesis and peripheral blood quantitative indicators in rats with Walker-256 carcinoma at the doxorubicin and paclitaxel chemotherapy. Materials and Methods. Experiments have been carried out on 83 Wistar female rats of weight 150-250 grams. Doxorubicin in a dose of 4mg/kg and paclitaxel in a dose of 6mg/kg were administered intraperitoneally on the 11th day of experiment. Xymedon (100mg/kg) and mexidol (50mg/kg) were administered separately and in combination with each other, starting with the 11th day of experiment for 10 Says. We estimated myelograms and peripheral blood changes on the 14th and 22d day of the experiment. Results. Xymedon normalized differentiation of granulocytopoiesis cells more effectively than mexidol and reduced severity of erythrocytopenia on the 14th day of the experiment. Combination of xymedon and mexidol accelerated granulocytes differentiation more effectively than separated use of these medicines. It was accompanied by more effective increase of neutrophils number in peripheral blood. Despite the increase of poly-chromatophil normocytes number in bone marrow to the 22d day, the erythrocytes number in blood was not differed from one at separated use of these medicines. Conclusion. Myeloprotective effect of xymedon exceeds the effect of mexidol one. The combination of xymedon and mexidol accelerates granulocytes differentiation more effectively than separated use of these medicines.
| Reference Key |
a.v.2015saratovskijmyeloprotective
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Siprov A.V.;Masyagin V.A. |
| Journal | respirology (carlton, vic) |
| Year | 2015 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.