glucose fluctuations during gestation: an additional tool for monitoring pregnancy complicated by diabetes

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ID: 202664
2013
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Abstract
Continuous glucose monitoring (CGM) gives a unique insight into magnitude and duration of daily glucose fluctuations. Limited data are available on glucose variability (GV) in pregnancy. We aimed to assess GV in healthy pregnant women and cases of type 1 diabetes mellitus or gestational diabetes (GDM) and its possible association with HbA1c. CGM was performed in 50 pregnant women (20 type 1, 20 GDM, and 10 healthy controls) in all three trimesters of pregnancy. We calculated mean amplitude of glycemic excursions (MAGE), standard deviation (SD), interquartile range (IQR), and continuous overlapping net glycemic action (CONGA), as parameters of GV. The high blood glycemic index (HBGI) and low blood glycemic index (LBGI) were also measured as indicators of hyperhypoglycemic risk. Women with type 1 diabetes showed higher GV, with a 2-fold higher risk of hyperglycemic spikes during the day, than healthy pregnant women or GDM ones. GDM women had only slightly higher GV parameters than healthy controls. HbA1c did not correlate with GV indicators in type 1 diabetes or GDM pregnancies. We provided new evidence of the importance of certain GV indicators in pregnant women with GDM or type 1 diabetes and recommended the use of CGM specifically in these populations.
Reference Key
dalfr2013internationalglucose Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;M. G. Dalfrà;N. C. Chilelli;G. Di Cianni;G. Mello;C. Lencioni;S. Biagioni;M. Scalese;G. Sartore;A. Lapolla
Journal zhonghua wei zhong bing ji jiu yi xue
Year 2013
DOI
10.1155/2013/279021
URL
http://dx.doi.org/10.1155/2013/279021
Keywords
clinical endocrinology diseases of the endocrine glands

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