nitrous oxide persistently alleviates pain hypersensitivity in neuropathic rats: a dose-dependent effect
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ID: 202168
2015
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Abstract
BACKGROUND: Despite numerous pharmacological approaches, there are no common analgesic drugs that produce meaningful relief for the majority of patients with neuropathic pain. Although nitrous oxide (N2O) is a weak analgesic that acts via opioid-dependent mechanisms, it is also an antagonist of the N-methyl-D-aspartate receptor (NMDAR). The NMDAR plays a critical role in the development of pain sensitization induced by nerve injury.
| Reference Key |
boujema2015painnitrous
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|---|---|
| Authors | ;Meric Ben Boujema;Emilie Laboureyras;Jan Pype;Baptiste Bessière;Guy Simonnet |
| Journal | chemistryselect |
| Year | 2015 |
| DOI |
10.1155/2015/809059
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| URL | |
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