mechanistic study of the spiroindolones: a new class of antimalarials
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ID: 202115
2012
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Abstract
During the synthesis of the new antimalarial drug candidate NITD609, a high degree of diastereoselectivity was observed in the Pictet-Spengler reaction. By isolating both the <strong>4<em>E</em></strong> and <strong>4<em>Z</em></strong> imine intermediates, a systematic mechanistic study of the reaction under both kinetic and thermodynamic conditions was conducted. This study provides insight into the source of the diastereoselectivity for this important class of compounds.
| Reference Key |
keller2012moleculesmechanistic
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|---|---|
| Authors | ;Thomas H. Keller;Bryan K. S. Yeung;Louis-Sebastian Sonntag;Seh Yong Leong;Peiling Yap;Bin Zou |
| Journal | Journal of ethnopharmacology |
| Year | 2012 |
| DOI |
10.3390/molecules170910131
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| URL | |
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