executive functions as predictors of functional performance in mild alzheimer's dementia and mild cognitive impairment elderly funções executivas como preditores do desempenho funcional em idosos com demência de alzheimer em fase inicial e comprometimento cognitivo leve

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ID: 202004
2013
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Abstract
Cognitive impairment and depressive symptoms are associated with worse functionality phenotype in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) elderly. The present study aims to investigate the association between the impairment of executive functions and episodic memory, the presence of depressive symptoms with the functionality of these patients. One hundred and eighteen participants diagnosed with AD or MCI who underwent neuropsychological examination covering various domains of episodic memory and executive functions and the answered the Geriatric Depression Scale. Caregivers answered a scale of Activities of Daily Living. The cognitive variables were reduced through factor analysis to three components (Executive Functions, Memory Episodic and Working Memory) and, along with depressive symptoms, used as predictors in a linear regression model, where only Executive Functions were related to functionality (R²= 0.30). The results suggest that executive functions are particularly relevant for functionality in these patients.
O comprometimento cognitivo e os sintomas depressivos são associados a um pior fenótipo funcional em idosos com Alzheimer (DA) e Comprometimento Cognitivo Leve (CCL). O presente estudo almeja investigar a associação entre o comprometimento das funções executivas, da memória episódica e a presença de sintomas depressivos com o desempenho funcional nesses pacientes. Cento e dezoito idosos com DA ou CCL realizaram exame neuropsicológico, contemplando diversos domínios das Funções Executivas e Memória episódica, além da Escala de Depressão Geriátrica. Os cuidadores responderam uma escala de atividades de vida diária. As variáveis cognitivas foram reduzidas por meio de análise fatorial a três componentes (Funções Executivas, Memória Episódica e Memória de Trabalho) e junto aos sintomas depressivos utilizados como preditores em um modelo de regressão linear, onde apenas as Funções Executivas se relacionaram à funcionalidade (R² = 0.30). Os resultados sugerem que as Funções Executivas são particularmente relevantes à funcionalidade desses pacientes.
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Authors ;Jonas Jardim de Paula;Leandro Fernandes Malloy-Diniz
Journal mycopathologia
Year 2013
DOI
DOI not found
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-294X2013000100019
Keywords
episodic memory executive functions psychology religionpsychology atividades cotidianas memoria function activities

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