association between hypertension and chronic arsenic exposure in drinking water: a cross-sectional study in bangladesh
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2012
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Abstract
Chronic arsenic exposure and its association with hypertension in adults are inconclusive and this cross-sectional study investigated the association. The study was conducted between January and July 2009 among 1,004 participants from 1,682 eligible women and men aged ≥30 years living in rural Bangladesh who had continuously consumed arsenic-contaminated drinking water for at least 6 months. Hypertension was defined as systolic blood pressure ≥140 mmHg (systolic hypertension) and diastolic blood pressure ≥90 mmHg (diastolic hypertension). Pulse pressure was calculated by deducting diastolic from systolic pressure and considered to be increased when the difference was ≥55 mmHg. The prevalence of hypertension was 6.6% (95% CI: 5.1–8.3%). After adjustment for other factors, no excess risk of hypertension was observed for arsenic exposure >50μg/L or to that of arsenic exposure as quartiles or as duration. Arsenic concentration as quartiles and >50 μg/L did show a strong relationship with increased pulse pressure (adjusted OR: 3.54, 95% CI: 1.46–8.57), as did arsenic exposure for ≥10 years (adjusted OR: 5.25, 95% CI: 1.41–19.51). Arsenic as quartiles showed a dose response relationship with increased pulse pressure. Our study suggests an association between higher drinking water arsenic or duration and pulse pressure, but not hypertension.
| Reference Key |
milton2012internationalassociation
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| Authors | ;Abul Hasnat Milton;Shahnaz Akter;Sheikh Mohammad Shahidullah;Syed Azim;Ayesha Akhter;Catherine D'Este;Mark McEvoy;Sheikh Mohammad Nazmul Hassan;Ismail Khan;John Attia;Mohammad Rafiqul Islam |
| Journal | archives of biochemistry and biophysics |
| Year | 2012 |
| DOI |
10.3390/ijerph9124522
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| URL | |
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