synthesis, antimicrobial, anticancer evaluation and qsar studies of n′-substituted benzylidene/2-hydroxynaphthalen-1-ylmethylene/3-phenylallylidene/5-oxopentylidene -4-(2-oxo-2-(4h-1,2,4-triazol-4-yl) methylamino)benzohydrazides
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ID: 201740
2017
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Abstract
A series of 1,2,4-triazole derivatives (1–17) was synthesized and evaluated for its antimicrobial and anticancer potentials. Antimicrobial screening of the synthesized compounds indicated that they were most potent against Aspergillus niger and compound 14 was found to be the most active. Compound 7 showed appreciable anticancer activity against HCT 116, a colon cancer cell line. QSAR analysis indicated the importance of topological parameter, valence third order molecular connectivity index (3χv) and electronic parameter, dipole moment (μ) in describing the antimicrobial activity of the synthesized compounds.
| Reference Key |
tahlan2017arabiansynthesis,
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|---|---|
| Authors | ;Sumit Tahlan;Pradeep Kumar;Kalavathy Ramasamy;Vasudevan Mani;Rakesh Kumar Mishra;Abu Bakar Abdul Majeed;Balasubramanian Narasimhan |
| Journal | Behavioural brain research |
| Year | 2017 |
| DOI |
10.1016/j.arabjc.2013.07.029
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| URL | |
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