breaking the cycle: an insight into the role of erα in eukaryotic cell cycles

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ID: 201647
2011
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Abstract
There have been numerous reviews written to date on estrogen receptor (ER), focusing on topics such as its role in the etiology of breast cancer, its mode of regulation, its role as a transcriptional activator and how to target it therapeutically, just to name a few. One reason for so much attention on this nuclear receptor is that it acts not only as a prognostic marker, but also as a target for therapy. However, a relatively undiscovered area in the literature regarding ER is how its activity in the presence and absence of ligand affects its role in proliferation and cell cycle transition. In this review, we provide a brief overview of ER signaling, ligand dependent and independent, genomic and non-genomic, and how these signaling events affect the role of ER in the mammalian cell cycle.
Reference Key
moghadam2011journalbreaking Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sonia Javan Moghadam;Amanda M Hanks;Khandan Keyomarsi
Journal italian journal of mycology
Year 2011
DOI
10.4103/1477-3163.90440
URL
http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2011;volume=10;issue=1;spage=25;epage=25;aulast=Moghadam
Keywords
cell cycle estradiol Oncology including cancer and carcinogens tumors

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